Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure

The Effect of Continuous Positive Airway Pressure in a Mouse Model of Hyperoxic Neonatal Lung Injury.

BACKGROUND Continuous positive airway pressure (CPAP) and supplemental oxygen have become the mainstay of neonatal respiratory support in preterm infants. Although oxygen therapy is associated with respiratory morbidities including bronchopulmonary dysplasia (BPD), the long-term effects of CPAP on lung function are largely unknown. We used a hyperoxia-induced mouse model of BPD to explore the e...

A Comparison between Nasal Intermittent Positive Pressure Ventilation and Nasal Continuous Positive Airway Pressure Ventilation in the Treatment of Neonatal Respiratory Distress Syndrome

Background: Nasal intermittent positive pressure ventilation (NIPPV) is a non-invasive ventilatory mode, which delivers mechanical ventilation via nasal tubes or prongs. The present study was conducted to compare the efficacy of NIPPV and nasal continuous positive airway pressure ventilation (NCPAP) in reducing the need for intubation in preterm infants with respiratory distress syndrome (RDS)....

Use of continuous positive airway pressure reduces airway reactivity in adults with asthma.

Asthma is characterised by airway hyperreactivity, which is primarily treated with β-adrenergic bronchodilators and anti-inflammatory agents. However, mechanical strain during breathing is an important modulator of airway responsiveness and we have previously demonstrated in animal models that continuous positive airway pressure (CPAP) resulted in lower in vivo airway reactivity. We now evaluat...

Comparison of Nasal Continuous Positive Airway Pressure Therapy with and without Prophylactic Surfactant in Preterm Neonates

Background: Preterm labor is at risk for respiratory distress syndrome (RDS) and sometimes requires to mechanical ventilation (MV) and surfactant therapy. Continuous positive airway pressure (CPAP) and Nasal Continuous positive airway pressure (NCPAP) are the methods of respiratory support especially for using in RDS of neonates. In other method surfactant is administered to babies via tracheal...

Intraocular Pressure during Continuous Positive Airway Pressure